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Table 2 Results from linear regression analyses for the associations between birthweight and age at events related to menarche and menopause

From: Associations between birthweight and preterm birth and the ages at menarche and menopause

 

Birth weight category

β (SE)

P

 

< 6 lbs.

N = 7,096

6 lbs.–7 lbs. 15 oz.

N = 52,661

8 lbs.–9 lbs. 15 oz.

N = 15,591

≥ 10 lbs.

N = 2,680

Global P

Menarche-related

 

Age at menarche

     
  

Unadjusted (n=77,720)

-0.041 (0.02)

0.03

Ref

-0.023 (0.01)

0.09

0.023 (0.03)

0.42

0.049

  

Adj. for demographics (n=74,840)

-0.044 (0.02)

0.02

Ref

0.005 (0.01)

0.72

0.046 (0.03)

0.12

< 0.0001

  

Adj. for demographic and lifestyle factors (n=65,447)

-0.047 (0.02)

0.02

Ref

-0.003 (0.01)

0.82

0.032 (0.03)

0.31

< 0.0001

 

Age at first regular period

     
  

Unadjusted (n=65,289)

-0.026 (0.03)

0.31

Ref

-0.043 (0.02)

0.02

-0.050 (0.04)

0.21

0.07

  

Adj. for demographics (n=62,910)

-0.016 (0.03)

0.54

Ref

-0.017 (0.02)

0.36

-0.011 (0.04)

0.79

< 0.0001

  

Adj. for demographic and lifestyle factors (n=55,274)

-0.011 (0.03)

0.68

Ref

-0.016 (0.02)

0.42

-0.026 (0.04)

0.54

< 0.0001

Reproductive window

 

Reproductive window (years)

     
  

Unadjusted (n=54,348)

-0.455 (0.09)

< 0.0001

Ref

0.058 (0.07)

0.37

-0.409 (0.14)

0.004

< 0.0001

  

Adj. for demographics (n=52,445)

-0.403 (0.09)

< 0.0001

Ref

0.034 (0.07)

0.61

-0.466 (0.14)

0.001

< 0.0001

  

Adj. for demographic and lifestyle factors (n=46,036)

-0.287 (0.10)

0.004

Ref

0.029 (0.07)

0.67

-0.283 (0.15)

0.06

< 0.0001

Menopause-related

 

Age at last regular period

     
  

Unadjusted (n=70,263)

-0.585 (0.09)

< 0.0001

Ref

0.042 (0.06)

0.51

-0.135 (0.14)

0.33

< 0.0001

  

Adj. for demographics (n=67,805)

-0.528 (0.09)

< 0.0001

Ref

0.036 (0.06)

0.57

-0.217 (0.14)

0.12

< 0.0001

  

Adj. for demographic and lifestyle factors (n=59,460)

-0.445 (0.09)

< 0.0001

Ref

0.063 (0.07)

0.35

-0.083 (0.15)

0.57

< 0.0001

 

Age at last vaginal bleeding

     
  

Unadjusted (n=71,538)

-0.717 (0.10)

< 0.0001

Ref

0.034 (0.07)

0.62

-0.214 (0.15)

0.16

< 0.0001

  

Adj. for demographics (n=69,009)

-0.631 (0.10)

< 0.0001

Ref

0.027 (0.07)

0.70

-0.311 (0.15)

0.04

< 0.0001

  

Adj. for demographic and lifestyle factors (n=60,492)

-0.524 (0.10)

< 0.0001

Ref

0.048 (0.07)

0.52

-0.151 (0.16)

0.35

< 0.0001

 

Age at natural menopause

     
  

Unadjusted (n=62,015)

-0.494 (0.08)

< 0.0001

Ref

0.060 (0.06)

0.32

-0.308 (0.13)

0.02

< 0.0001

  

Adj. for demographics (n=59,822)

-0.450 (0.09)

< 0.0001

Ref

0.060 (0.06)

0.32

-0.342 (0.13)

0.01

< 0.0001

  

Adj. for demographic and lifestyle factors (n=52,416)

-0.350 (0.09)

< 0.0001

Ref

0.059 (0.06)

0.35

-0.159 (0.14)

0.25

< 0.0001

 

Age at natural menopause (conservative)

    
  

Unadjusted (n=54,413)

-0.478 (0.09)

< 0.0001

Ref

0.041 (0.06)

0.52

-0.361 (0.14)

0.01

< 0.0001

  

Adj. for demographics (n=52,506)

-0.432 (0.09)

< 0.0001

Ref

0.043 (0.06)

0.50

-0.391 (0.14)

0.01

< 0.0001

  

Adj. for demographic and lifestyle factors (n=46,084)

-0.317 (0.10)

0.001

Ref

0.035 (0.07)

0.61

-0.219 (0.15)

0.14

< 0.0001

  1. Results presented as beta (standard error) and p-value. Global P-value is testing for a linear tread. Demographic factors include age, race, ethnicity, region, and BMI. Lifestyle factors include smoking status, education, normalized socioeconomic status (NSES), and alcohol use. For the age at natural menopause analyses, participants were removed if they reported: having a bilateral oophorectomy prior to menopause; having an oophorectomy prior to menopause but did not know if it was unilateral or bilateral; or if they had an unknown oophorectomy status. For the conservative age at natural menopause, participants were also removed if they reported having a hysterectomy prior to menopause or had an unknown hysterectomy status
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BMC Women's Health

ISSN: 1472-6874

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